| Guillaume Plessis | |
| Birth Date: | 16 January 1985 |
| Birth Place: | Saint-Denis, Réunion |
| Position: | Defensive midfielder |
| Youthyears1: | –2004 |
| Youthclubs1: | Lens |
| Years1: | 2004–2005 |
| Years2: | 2005 |
| Years3: | 2005–2007 |
| Years4: | 2007–2008 |
| Years5: | 2008–2010 |
| Years6: | 2010–2011 |
| Clubs1: | Lens |
| Clubs2: | Everton |
| Clubs3: | Clermont Foot |
| Clubs4: | Boulogne |
| Clubs5: | Martigues |
| Clubs6: | Béziers |
| Caps1: | 0 |
| Caps2: | 0 |
| Caps3: | 9 |
| Caps4: | 2 |
| Caps5: | 0 |
| Caps6: | 17 |
| Goals1: | 0 |
| Goals2: | 0 |
| Goals3: | 0 |
| Goals4: | 0 |
| Goals5: | 0 |
| Goals6: | 0 |
| Nationalyears1: | 2002 |
| Nationalteam1: | France U17 |
| Nationalcaps1: | 3 |
| Nationalgoals1: | 1 |
Guillaume Plessis (born 16 January 1985) is a former professional footballer who played as a midfielder.
Plessis started his career with Lens. In January 2005, he joined Premier League club Everton on a six-month deal but failed to make a first team appearance.[1] He has also played for Clermont Foot and Martigues.
Plessis was part of the France U17 squad for the 2002 UEFA European Under-17 Championship.[2]
Plessis's younger brother Damien was also a professional footballer.