| Guilherme Melo | |
| Birth Name: | Guilherme Cavalcante de Melo |
| Birth Date: | 25 June 1952 |
| Birth Place: | Teresina, Fourth Brazilian Republic |
| Death Place: | Teresina, Brazil |
| Party: | PDS PPR PP PDT PMDB |
| Office: | 45th Governor of Piauí |
| Term Start: | 30 March 1994 |
| Term End: | 1 January 1995 |
| Office2: | Vice-Governor of Piauí |
| Term Start2: | 15 March 1991 |
| Term End2: | 30 March 1994 |
| Predecessor2: | Lucídio Portela Nunes |
| Office3: | Member of the Legislative Assembly of Piauí |
| Term Start3: | 1 February 1987 |
| Term End3: | 1 February 1991 |
Guilherme Cavalcante de Melo (25 June 1952 – 21 April 2021) was a Brazilian politician, businessman, and lawyer.[1] He served as Governor of Piauí, Vice-Governor of Piauí, and was a member of the Legislative Assembly of Piauí.
Guilherme was the son of and Luzia Cavalcante Melo. He earned a degree in business from the University Center of Brasília and began working at Banco do Brasil the Central Bank of Brazil. He became an advisor to the Empresa Brasileira de Assistência Técnica e Extensão Rural and the Chamber of Deputies. He then earned a degree in law from the Federal University of Piauí in 1984.[2]
Melo was a member of the Brazilian Democratic Movement (PMDB) before joining the Democratic Social Party (PDS) and serving in the government of but stepped down and was elected to the Legislative Assembly of Piauí in .[3] In, he was chosen to run as Vice-Governor of Piauí alongside, who became Governor.[4] Melo became governor in 1994 when Neto resigned to seek a seat on the Brazilian Senate.[7] He left the Governorship the following year after he declined to seek re-election. In 2006, he ran for a seat on the Legislative Assembly of Piauí as a member of the Democratic Labour Party, but was unsuccessful.
Guilherme Melo died from brain cancer in Teresina on 21 April 2021, at the age of 68.[5]