| Guilford Creek | |
| Pushpin Map: | New York |
| Pushpin Map Caption: | Location of the mouth of Guilford Creek |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | New York |
| Source1 Coordinates: | 42.4292°N -75.5163°W |
| Mouth: | Unadilla River |
| Mouth Coordinates: | 42.3326°N -75.4052°W[1] |
| Mouth Elevation: | 961feet |
Guilford Creek also known as "Guilford Pond Creek" is a river in Chenango County, New York. It flows into Unadilla River northwest of Sidney.