| Settlement Type: | municipality |
| Official Name: | Guijo de Santa Bárbara |
| Subdivision Type: | Country |
| Subdivision Name: | Spain |
| Subdivision Type1: | Autonomous community |
| Subdivision Name1: | Extremadura |
| Subdivision Type2: | Province |
| Subdivision Name2: | Cáceres |
| Subdivision Type3: | Comarca |
| Subdivision Name3: | La Vera |
| Area Total Km2: | 35 |
| Elevation M: | 876 |
| Population Density Km2: | auto |
| Timezone: | CET |
| Utc Offset: | +1 |
| Timezone Dst: | CEST |
| Utc Offset Dst: | +2 |
| Latitude: | 40º09' N |
| Longitude: | 5º39' W |
Guijo de Santa Bárbara is a municipality located in the province of Cáceres, Extremadura, Spain. According to the 2005 census (INE), the municipality has a population of 429 inhabitants.
This village is located at Gredos Mountains and a river known as Garganta de Jaranda. Most of the land of the municipality is placed inside a natural space (LIC de la Sierra de Gredos).
The village is a typical destination for holidays, due to be near to Madrid (2 hours by car), and because of the opportunities for walking in the mountain and the river.
The population mainly works in touristic services (hostels, bars, etc.) and agriculture.
Main festivities are celebrated in August (14-15), September (8 and 9), and December (2-4). Other events are Viriato Day in May and Trashumancia's Day in June–July.