| Type: | Cardinal |
| Honorific Prefix: | His Eminence |
| Guglielmo Sanfelice d'Acquavilla | |
| Honorific Suffix: | O.S.B. Cas. |
| Archbishop of Naples | |
| Church: | Roman Catholic Church |
| Archdiocese: | Naples |
| See: | Naples |
| Appointed: | 15 July 1878 |
| Term End: | 3 January 1897 |
| Predecessor: | Sisto Riario Sforza |
| Successor: | Vincenzo Maria Sarnelli |
| Other Post: | Cardinal-Priest of San Clemente (1884–97) |
| Ordination: | 15 March 1857 |
| Consecration: | 21 July 1878 |
| Consecrated By: | Alessandro Franchi |
| Cardinal: | 24 March 1884 |
| Created Cardinal By: | Pope Leo XIII |
| Rank: | Cardinal-Priest |
| Birth Name: | Guglielmo Sanfelice d'Acquavilla |
| Birth Date: | 14 April 1834 |
| Birth Place: | Aversa, Kingdom of the Two Sicilies |
| Death Place: | Naples, Kingdom of Italy |
| Buried: | Naples Cathedral |
| Parents: | Giuseppe Sanfelice d'Acquavilla Giovanna Di Martino |
Guglielmo Sanfelice d'Acquavilla O.S.B.Cas. (14 April 1834 – 3 January 1897) was a Cardinal of the Roman Catholic Church and Archbishop of Naples.
Sanfelice d'Acquavilla was born in Aversa, Italy, on 14 April 1834.
He was appointed Archbishop of Naples in 1878 and served until his death in 1897.[1]
He was made cardinal by Pope Leo XIII in 1884.
Sanfelice d'Acquavilla died in Naples on 3 January 1897.