| Guglielmo Brezzi | |
| Birth Date: | 24 December 1898 |
| Birth Place: | Alessandria, Italy |
| Death Place: | Alessandria, Italy |
| Position: | Striker |
| Years1: | 1915–1916 |
| Years2: | 1919–1920 |
| Years3: | 1920–1923 |
| Clubs2: | Genoa |
| Clubs3: | Alessandria |
| Caps1: | 10 |
| Caps2: | 19 |
| Caps3: | 59 |
| Goals1: | 12 |
| Goals2: | 16 |
| Goals3: | 30 |
| Nationalyears1: | 1920–1923 |
| Nationalteam1: | Italy |
| Nationalcaps1: | 8 |
| Nationalgoals1: | 5 |
Guglielmo Brezzi (pronounced as /it/; 24 December 1898 – 7 April 1926) was an Italian professional footballer who played as a forward.
At club level, Brezzi played for Genoa C.F.C. and U.S. Alessandria Calcio 1912. Brezzi made his debut for the Italy national football team on 18 January 1920 in a game against France and scored a hat-trick in a 9–4 victory. He represented Italy at the 1920 Summer Olympics.[1]