The Guayquiraró River (Spanish, Río Guayquiraró) is a river in the Mesopotamic northeastern region of Argentina. It is born in the middle section of the border between the provinces of Entre Ríos and Corrientes, fed from several streams on its right-hand basin. It flows west along the interprovincial border for about 110km (70miles), then emptying into the Paraná River, at a base level of about 26m (85feet) AMSL.
The river's drainage basin covers an area of 3150km2, and its mean annual flow is 21.7m3/s.