| Guayo River | |
| Pushpin Map: | USA Puerto Rico |
| Source1 Location: | Barrio Collores, Juana Diaz |
| Mouth Location: | Rio Inabon (Ponce) |
| Progression: | Municipality of Juana Diaz |
| Subdivision Type1: | Commonwealth |
| Subdivision Name1: | Puerto Rico |
| Subdivision Type2: | Municipality |
| Subdivision Name2: | Juana Díaz |
| Source1 Elevation: | 141 ft |
| Tributaries Right: | Quebrada Indalecia |
The Guayo River (Spanish; Castilian: Río Guayo) is a river near barrio Collores in the municipality of Juana Diaz, Puerto Rico.[1]