| Guayabero River | |
| Mouth Location: | 2.5787°N -72.7692°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Colombia |
The Guayabero River is a river of Colombia. It is primarily located in the Meta Department, forming a portion of its border with the Guaviare Department. It is part of the Orinoco River basin. Its confluence with the Ariari River gives rise to the Guaviare River, one of the Orinoco's largest tributaries.