| Guavio River | |
| Mouth Location: | Upía River |
| Subdivision Type1: | Country |
| Subdivision Name1: | Colombia |
Guavio River (Spanish: Río Guavio) is a river of central Colombia. It is a right tributary of the Upía River, in the drainage area of the Orinoco.[1]
Important tributaries are the Chivor and Garagoa Rivers.
The Alberto Lleras Dam is situated on the Guavio River.