| Guasaule River | |
| Map Size: | 280 |
| Pushpin Map Size: | 280 |
| Subdivision Type1: | Countries |
| Subdivision Name1: | Nicaragua and Honduras |
| Length: | NaNkm (-2,147,483,648miles) |
| Mouth Coordinates: | 13.0167°N -86.9833°W |
| Mouth Elevation: | 20feet |
The Guasaule River (Spanish; Castilian: Río Guasaule) is a river in northern Nicaragua and southern Honduras.[1]