| Guapi River | |
| Pushpin Map: | Colombia |
| Pushpin Map Caption: | Mouth location in Colombia |
| Mouth Coordinates: | 2.6424°N -77.9114°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Colombia |
The Guapi River (Spanish; Castilian: Río Guapi) is a river of Colombia that flows into the Pacific Ocean near the town of Guapi, Cauca.
The mouth of the river has extensive stands of mangroves, part of the Esmeraldes-Pacific Colombia mangroves ecoregion.