| Grande River | |
| Map: | Riograndeboliviarivermap.png |
| Map Size: | 300 |
| Pushpin Map Size: | 300 |
| Subdivision Type1: | Country |
| Subdivision Name1: | Bolivia |
| Length: | 820km (510miles)[1] |
| Source1: | Sierra de Cochabamba |
| Source1 Elevation: | 3693m (12,116feet) |
| Mouth: | Mamoré River |
| Mouth Elevation: | 174m (571feet) |
The Río Grande (or Río Guapay) in Bolivia rises on the southern slope of the Cochabamba mountains, east of the city Cochabamba, at . At its source, it is known as the Rocha River. It crosses the Cochabamba valley basin in a westerly direction, turning south east after and after another 50km (30miles) joining the Arque River at and an elevation of 2350m (7,710feet).
From this junction the river receives the name Caine River for 162km (101miles) and continues to flow in a south easterly direction, before it is called Río Grande. After a total of 500km (300miles) the river turns north east and in a wide curve flows round the lowland city of Santa Cruz.
After 1438km (894miles), the Río Grande joins the Ichilo River at which is a tributary to the Mamoré.