Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase explained

guanosine-3′,5′-bis(diphosphate) 3′-diphosphatase
Ec Number:	3.1.7.2
Cas Number:	70457-12-4
Go Code:	0008893

The enzyme guanosine-3′,5′-bis(diphosphate) 3′-diphosphatase (EC 3.1.7.2)^{[1] [2]} catalyzes the reaction

guanosine 3′,5′-bis(diphosphate) + H₂O

\rightleftharpoons GDP + diphosphate

This enzyme belongs to the family of hydrolases, specifically those acting on diphosphoric monoester bonds. The systematic name is guanosine-3′,5′-bis(diphosphate) 3′-diphosphohydrolase. Other names in common use include guanosine-3′,5′-bis(diphosphate) 3′-pyrophosphatase, PpGpp-3'-pyrophosphohydrolase, and PpGpp phosphohydrolase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

Notes and References

1. Heinemeyer EA, Richter D . 1978 . Characterization of the guanosine 5'-triphosphate 3′-diphosphate and guanosine 5′-diphosphate 3′-diphosphate degradation reaction catalyzed by a specific pyrophosphorylase from Escherichia coli . Biochemistry . 17 . 5368 - 72 . 365225 . 10.1021/bi00618a007 . 25 .
2. Richter D, Fehr S, Harder R . 1979 . The guanosine 3′,5′-bis(diphosphate) (ppGpp) cycle. Comparison of synthesis and degradation of guanosine 3′,5′-bis(diphosphate) in various bacterial systems . Eur. J. Biochem. . 99 . 57 - 64 . 114395 . 10.1111/j.1432-1033.1979.tb13230.x . 1 . free .