| Guanare | |
| Official Name: | Guanare |
| Settlement Type: | City |
| Pushpin Map: | Venezuela |
| Subdivision Type: | Country |
| Subdivision Type1: | State |
| Subdivision Type2: | Municipality |
| Subdivision Name: | Venezuela |
| Subdivision Name1: | Portuguesa |
| Established Title: | Founded |
| Established Date: | 3 November 1591 |
| Leader Title: | Mayor |
| Area Total Km2: | 2008 |
| Population As Of: | 2022 |
| Population Total: | 112,286 |
| Population Density Km2: | 100.63 |
| Timezone: | VET |
| Utc Offset: | −4 |
| Blank1 Name: | Climate |
| Blank1 Info: | Aw |
| Coordinates: | 9.0436°N -69.7489°W |
| Elevation M: | 183 |
| Population Blank1 Title: | Demonym |
| Population Blank1: | Guanareño(a) |
| Area Code: | 0257 |
| Postal Code Type: | Postal code |
| Postal Code: | 3350 |
| Website: | Alcaldía de Guanare |
| Footnotes: | The area and population figures are for the municipality |
Guanare (pronounced as /es/) is the capital and most populated city of Portuguesa State, Venezuela. It is where la Virgen de Coromoto is said to have appeared to a Coromoto Indian.
Guanare was founded on 3 November 1591 by João Fernandes de Leão Pacheco (1543–1593), a Portuguese captain from Portimão.
Located at the edge of the Southwestern floodplains, near the Andes foothills, Guanare is in a region known for livestock and agricultural production. Guanare is also the location of one of the campuses of UNELLEZ