| Guáitara River | |
| Pushpin Map: | Colombia |
| Pushpin Map Caption: | Mouth location in Colombia |
| River System: | Patía River |
| Mouth Coordinates: | 1.5878°N -77.4464°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Colombia |
The Guáitara River (Spanish; Castilian: Río Guáitara) is a river of Colombia. It is a tributary of the Patía River.
The Guáitara River rises on the border of Ecuador and Colombia on the slopes of Chiles Volcano and initially flows east, eventually turning north to join the Patia. It is called the Carchi River in Ecuador.
In its lower reaches the river is in the Patía Valley dry forests ecoregion.