| Tourney Name: | Guadiana Trophy |
| Year: | 2010 |
| Country: | Portugal |
| Dates: | 30 July 2010 – 1 August 2010 |
| Num Teams: | 3 |
| Venues: | Complexo Desportivo de Vila Real de Santo António |
| Champion Other: | Benfica |
| Count: | 4 |
| Third Other: | Feyenoord |
| Matches: | 3 |
| Goals: | 14 |
| Top Scorer: | 3 – Óscar Cardozo (Benfica) |
| Player: | Óscar Cardozo (Benfica) |
| Prevseason: | 2009 |
| Nextseason: | 2011 |
The 2010 Guadiana Trophy was the 10th edition of the competition and took place between 30 July and 1 August 2010. It featured Benfica, Feyenoord, and Aston Villa.
Benfica won its fourth title after beating Aston Villa in the final by a score of 4-1.