| Guadalupe | |
| Settlement Type: | Municipality |
| Pushpin Label Position: | above |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Mexico |
| Subdivision Type: | Country |
| Subdivision Name: |  Mexico |
| Subdivision Type1: | State |
| Subdivision Name1: | Zacatecas |
| Subdivision Type2: | Municipal seat |
| Subdivision Name2: | Guadalupe |
| Area Total Km2: | 804 |
| Population As Of: | 2020 |
| Population Total: | 211740 |
| Population Blank1 Title: | Ethnicities |
| Population Blank2 Title: | Religions |
| Coordinates: | 22.7528°N -102.5078°W |
Guadalupe is one of 58 municipalities located in the Mexican state of Zacatecas. Its municipal seat is located in the town of Guadalupe. It has an area of 804 km². The municipality is located in the southeastern part of the state.