| Official Name: | Guadalupe |
| Settlement Type: | Town |
| Pushpin Map: | Sao Tome |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location on São Tomé Island |
| Subdivision Type: | Country |
| Subdivision Name: | São Tomé and Príncipe |
| Subdivision Type1: | Island |
| Subdivision Name1: | São Tomé |
| Subdivision Type2: | District |
| Subdivision Name2: | Lobata |
| Population As Of: | 2012 |
| Population Total: | 7,604 |
| Timezone1: | WAT |
| Utc Offset1: | +1 |
| Coordinates: | 0.38°N 6.6381°W |
Guadalupe is a town located in the northern part of São Tomé Island, which is part of the island nation of São Tomé and Príncipe. It is the seat of Lobata District. Its population is 7,604 (2012 census).[1] Guadalupe lies 1.5 km northwest of Agostinho Neto, 10 km east of Neves and 11 km northwest of the capital São Tomé.