| Official Name: | Guadalupe |
| Pushpin Map: | Bolivia |
| Pushpin Map Caption: | Location in Bolivia |
| Subdivision Type: | Country |
| Subdivision Name: | Bolivia |
| Subdivision Type1: | Department |
| Subdivision Name1: | Potosí Department |
| Subdivision Type2: | Province |
| Subdivision Name2: | Sud Lípez Province |
| Subdivision Type3: | Municipality |
| Subdivision Name3: | San Antonio de Esmoruco Municipality |
| Subdivision Type4: | Canton |
| Subdivision Name4: | Guadalupe Canton |
| Unit Pref: | Imperial |
| Population As Of: | 2001 |
| Population Total: | 184 |
| Population Blank1 Title: | Ethnicities |
| Coordinates: | -21.8497°N -66.5139°W |
Guadalupe is a village in the Bolivian Potosí Department. It is the seat of the Guadalupe Canton, one of the two cantons of the San Antonio de Esmoruco Municipality which is the third municipal section of the Sud Lípez Province.
The village is located 40 km south-east of the provincial capital San Pablo de Lípez at an elevation of 4,173 m amsl at a tributary of Río San Juan del Oro.