| Guadalupe | |
| Native Name Lang: | es |
| Coordinates: | 38°N -12°W |
| Subdivision Name: |  Spain |
| Subdivision Type1: | Autonomous community |
| Subdivision Type2: | Province |
| Subdivision Name2: | Murcia |
| Subdivision Type3: | Comarca |
| Subdivision Name3: | Huerta de Murcia |
| Subdivision Type4: | Judicial district |
| Subdivision Name4: | Murcia |
| Subdivision Type5: | Municipality |
| Subdivision Name5: | Murcia |
| Unit Pref: | Metric |
| Area Footnotes: | [1] |
| Area Total Km2: | 6008 |
| Elevation M: | 57 |
| Population Footnotes: | [2] |
| Population Total: | 6242 |
| Population As Of: | 2011-01-01 |
| Population Density Km2: | auto |
| Timezone: | CET |
| Utc Offset: | +1 |
| Timezone Dst: | CEST |
| Utc Offset Dst: | +2 |
| Postal Code Type: | Postal code |
| Area Code Type: | Dialing code |
Guadalupe is a Spanish; Castilian: pedanía (village/suburban district) in the municipality of Murcia in the Region of Murcia, Spain. The main populated area is known as Guadalupe de Maciascoque.
El Escorial Murciano, the complex that contains the Universidad Católica San Antonio de Murcia and the Monasterio de los Jerónimos de San Pedro de la Ñora, an historic Hieronymite monastery, is located here.
Historically, in the Middle Ages, Guadalupe was home to a Jewish community until the expulsion of the Jews in 1492.[3]