| Guadalupe, Antioquia | |
| Settlement Type: | Municipality and town |
| Mapsize: | 250px |
| Pushpin Map: | Colombia |
| Pushpin Mapsize: | 250 |
| Pushpin Map Caption: | Location in Colombia |
| Coordinates: | 6.8175°N -75.2442°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Colombia |
| Subdivision Type1: | Department |
| Subdivision Name1: | Antioquia Department |
| Subdivision Type2: | Subregion |
| Subdivision Name2: | Northern |
| Established Title: | Foundation |
| Established Date: | 1757 |
| Leader Title: | Mayor |
| Leader Name: | César Augusto Agudelo |
| Area Total Km2: | 87 |
| Elevation M: | 1875 |
| Population Total: | 6286 |
| Population As Of: | 2002 |
| Population Density Km2: | auto |
| Timezone: | Colombia Standard Time |
| Utc Offset: | -5 |
Guadalupe is a town and municipality in the Colombian department of Antioquia. Part of the subregion of Northern Antioquia, it lies at an elevation of 1,875 m (6,152 ft) above sea level.