| Guémené-Penfao | |
| Native Name: | (Gallo) |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason ville fr Guémené-Penfao (Loire-Atlantique).svg |
| Arrondissement: | Châteaubriant-Ancenis |
| Canton: | Guémené-Penfao |
| Insee: | 44067 |
| Postal Code: | 44290 |
| Mayor: | Isabelle Barathon-Bazelle[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | Redon Agglomération |
| Coordinates: | 47.6308°N -1.8314°W |
| Elevation Min M: | 2 |
| Elevation Max M: | 83 |
| Area Km2: | 105.51 |
Guémené-Penfao (in French pronounced as /ɡemne pɛ̃fo/; Gallo: Gemenae, Breton: Gwenvenez-Penfaou) is a commune in the Loire-Atlantique department in western France, north of Nantes. The commune is widespread and includes the former communes of Beslé-sur-Vilaine and Guénouvry.
Its name comes from the Breton language: "gwen" (white), "menez" (hill, mountain), "pen" (head), and "faou" (beech tree). The main economic activity is agriculture.