| Guédébiné | |
| Settlement Type: | Commune and village |
| Pushpin Map: | Mali |
| Pushpin Label Position: | bottom |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Mali |
| Subdivision Type: | Country |
| Subdivision Name: |  Mali |
| Subdivision Type1: | Region |
| Subdivision Name1: | Kayes Region |
| Subdivision Type2: | Cercle |
| Subdivision Name2: | Diéma Cercle |
| Area Footnotes: | [1] |
| Area Total Km2: | 225 |
| Population As Of: | 2009 census |
| Population Footnotes: | [2] |
| Population Total: | 5106 |
| Population Density Km2: | auto |
| Population Blank1 Title: | Ethnicities |
| Utc Offset: | +0 |
| Coordinates: | 15.044°N -9.354°W |
| Elevation M: | 275 |
Guédébiné is a rural commune and village in the Cercle of Diéma in the Kayes Region of western Mali. The commune contains the main village of Guédébiné as well as Néma, Diakamody, Diopi, Karsala and Goulambé. In the 2009 census the commune had a population of 5,106.