Growth hormone 1 explained

Growth hormone 1, also known as pituitary growth hormone or simply as growth hormone (GH) somatotropin, is a protein that in humans is encoded by the GH1 gene.^[1]

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones that play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation, an arrangement thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.^[2]

See also

• Placental growth hormone
• Somatotropin family

Further reading

• Binder G . Isolated growth hormone deficiency and the GH-1 gene: update 2002. . Horm. Res. . 58 Suppl 3 . 3. 2–6 . 2003 . 12435888 . 10.1159/000066476. 34602772 .
• Waxman DJ, O'Connor C . Growth hormone regulation of sex-dependent liver gene expression. . Mol. Endocrinol. . 20 . 11 . 2613–29 . 2007 . 16543404 . 10.1210/me.2006-0007 . free .
• Cattini PA, Yang X, Jin Y, Detillieux KA . Regulation of the human growth hormone gene family: possible role for Pit-1 in early stages of pituitary-specific expression and repression. . Neuroendocrinology . 83 . 3–4 . 145–53 . 2006 . 17047377 . 10.1159/000095522 . 34757447 .
• Wagner K, Hemminki K, Försti A . The GH1/IGF-1 axis polymorphisms and their impact on breast cancer development . Breast Cancer Res. Treat. . 104 . 3 . 233–48 . 2007 . 17082888 . 10.1007/s10549-006-9411-9 . 13544290 .

Notes and References

1. Barsh GS, Seeburg PH, Gelinas RE . The human growth hormone gene family: structure and evolution of the chromosomal locus . Nucleic Acids Res . 11 . 12 . 3939–58 . Aug 1983 . 6306568 . 326017 . 10.1093/nar/11.12.3939 .
2. Web site: Entrez Gene: GH1 growth hormone 1.