Group II pyridoxal-dependent decarboxylases explained
| Symbol: | Pyridoxal_deC |
| Pyridoxal-dependent decarboxylase conserved domain |
| Pfam: | PF00282 |
| Pfam Clan: | CL0061 |
| Interpro: | IPR002129 |
| Prosite: | PDOC00329 |
| Scop: | 1js3 |
In molecular biology, group II pyridoxal-dependent decarboxylases are family of enzymes including aromatic-L-amino-acid decarboxylase (L-dopa decarboxylase or tryptophan decarboxylase), which catalyses the decarboxylation of tryptophan to tryptamine, tyrosine decarboxylase, which converts tyrosine into tyramine and histidine decarboxylase, which catalyses the decarboxylation of histidine to histamine.[1] [2]
Pyridoxal-5'-phosphate-dependent amino acid decarboxylases can be divided into four groups based on amino acid sequence. Group II includes glutamate, histidine, tyrosine, and aromatic-L-amino-acid decarboxylases.[3]
See also
Notes and References
- Ishii S, Mizuguchi H, Nishino J, Hayashi H, Kagamiyama H . Functionally important residues of aromatic L-amino acid decarboxylase probed by sequence alignment and site-directed mutagenesis . J. Biochem. . 120 . 2 . 369–76 . August 1996 . 8889823 . 10.1093/oxfordjournals.jbchem.a021422.
- Joseph DR, Sullivan PM, Wang YM, Kozak C, Fenstermacher DA, Behrendsen ME, Zahnow CA . Characterization and expression of the complementary DNA encoding rat histidine decarboxylase . Proc. Natl. Acad. Sci. U.S.A. . 87 . 2 . 733–7 . January 1990 . 2300558 . 53340 . 10.1073/pnas.87.2.733. 1990PNAS...87..733J . free .
- Sandmeier E, Hale TI, Christen P . Multiple evolutionary origin of pyridoxal-5'-phosphate-dependent amino acid decarboxylases . Eur. J. Biochem. . 221 . 3 . 997–1002 . May 1994 . 8181483 . 10.1111/j.1432-1033.1994.tb18816.x. free .
