| Type: | Gemeinde |
| Dissolved: | 1 January 2011 |
| Noautocat: | yes |
| Coordinates: | 51.6111°N 13.025°W |
| State: | Sachsen |
| District: | Nordsachsen |
| Elevation: | 78 |
| Area: | 56.49 |
| Population: | 1998 |
| Stand: | 2009-12-31 |
| Postal Code: | 04886 |
| Area Code: | 03421 |
| Licence: | TDO |
Großtreben-Zwethau is a former municipality in the district Nordsachsen, in Saxony, Germany. It was established in 1994 by the merger of the former municipalities Großtreben and Zwethau. On 1 January 2011, it was absorbed into the municipality Beilrode.