| Coordinates: | 51.3833°N 57°W |
| Image Plan: | Großkmehlen in OSL.svg |
| State: | Brandenburg |
| District: | Oberspreewald-Lausitz |
| Amt: | Ortrand |
| Elevation: | 108 |
| Area: | 13.75 |
| Postal Code: | 01990 |
| Area Code: | 035755 |
| Licence: | OSL |
| Gemeindeschlüssel: | 12 0 66 104 |
| Divisions: | 3 Ortsteile |
| Website: | www.grosskmehlen.de |
| Mayor: | Dietmar Bruntsch[1] |
| Leader Term: | 2024 - 29 |
Großkmehlen is a municipality in the Oberspreewald-Lausitz district, in southern Brandenburg, Germany. The places of the municipality Großkmehlen belong to the few places in the southern part of the district Oberspreewald-Lausitz, which are not located in Lusatia.[2]
From 1815 to 1944, Großkmehlen was part of the Prussian Province of Saxony and from 1944 to 1945 of the Province of Halle-Merseburg. From 1952 to 1990, it was part of the Bezirk Cottbus of East Germany.