| Coordinates: | 51.1167°N 20°W |
| Image Plan: | Großharthau in BZ.svg |
| State: | Sachsen |
| District: | Bautzen |
| Verwaltungsgemeinschaft: | Großharthau |
| Elevation: | 270 |
| Area: | 37.27 |
| Postal Code: | 01909 |
| Area Code: | 035954, 035200 Seeligstadt |
| Licence: | BZ, BIW, HY, KM |
| Gemeindeschlüssel: | 14625170 |
| Divisions: | 4 |
| Website: | www.grossharthau.de |
| Mayor: | Jens Krauße[1] |
| Leader Term: | 2022 - 29 |
| Party: | SPD |
Großharthau is a municipality in the east of Saxony, Germany. It belongs to the district of Bautzen and lies southwest of the eponymous city.
The municipality is situated at the northern edge of the Lausitzer Bergland (Lusatian Hills), near Bischofswerda.
Several villages belong to the municipality: