| Großer Landgraben | |
| Mouth Location: | Tollense |
| Mouth Coordinates: | 53.7918°N 13.3129°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Germany |
| Subdivision Type2: | States |
| Subdivision Name2: | Mecklenburg-Vorpommern |
The Großer Landgraben is a river of Mecklenburg-Vorpommern, Germany. It is formed at the confluence of Landgraben (west-flowing branch), Kleiner Landgraben (north-flowing branch) and Mittelgraben near Siedenbollentin. It flows into the Tollense in Klempenow.