| Große Schweimke | |
| Subdivision Type1: | Country |
| Subdivision Name1: | Germany |
| Subdivision Type2: | State |
| Subdivision Name2: | Lower Saxony |
| Subdivision Type3: | Location |
| Subdivision Name3: | Göttingen district |
| Source1 Location: | South of the Schindelkopf on the Acker ridge |
| Mouth Location: | On the Kleine Steinau |
| Progression: | Kleine Steinau→ |
| Tributaries Right: | Kleine Schweimke |
| Custom Label: | References |
The Große Schweimke is a river of Lower Saxony, Germany.
It is long and a tributary of the Kleine Steinau, north of Herzberg am Harz in the district of Göttingen. It rises at about 602 m above sea level and south of the Schindelkopf and roughly north of the Weinbergstraße road on the ridge known as Auf dem Acker. It flows initially in a southwesterly direction before swinging west and discharging into the Kleine Steinau.