| Große Sülze | |
| Mouth Coordinates: | 52.2264°N 11.644°W |
| Progression: | Schrote→ |
| Subdivision Type1: | Country |
| Subdivision Name1: | Germany |
| Subdivision Type2: | State |
| Subdivision Name2: | Saxony-Anhalt |
Große Sülze is a river of Saxony-Anhalt, Germany. It flows into the Schrote near Barleben. In English, Große Sülze means 'Big Brawn'. The following trees have been planted along its banks: Field Maple, Sycamore, Hornbeam, Ash and Linden.