| Große Kulmke | |
| Subdivision Type1: | Country |
| Subdivision Name1: | Germany |
| Subdivision Type2: | State |
| Subdivision Name2: | Lower Saxony |
| Subdivision Type3: | District |
| Subdivision Name3: | Göttingen |
| Length: | 6km (04miles) |
| Source1 Location: | near the Auf dem Acker ridge |
| Source1 Elevation: | 760 m |
| Mouth Location: | Sieber |
| Mouth Elevation: | 355 m |
| Basin Size: | 15km2 |
| Tributaries Right: | Hirschkappe, Bienenkappe, Kleine Kulmke |
| Tributaries Left: | Bornkappe |
| Custom Label: | References |
Große Kulmke is a river of Lower Saxony, Germany.
The Große Kulmke is a tributary of the Sieber in central Germany. It rises near the natural monument of Mönchskappenklippe near the ridge of Auf dem Acker, north-northeast of Sieber in the district of Göttingen in Lower Saxony. It then flows mainly in a southerly direction, separated from the Sieber by the Königsberg. After it merges with the Kleine Kulmke at an elevation of . The valley of the Große Kulmke is part of the Sieber Valley (Siebertal) nature reserve.