| Grindstone Run | |
| Name Other: | Tributary to Slippery Rock Creek |
| Map Size: | 300 |
| Pushpin Map: | USA Pennsylvania#USA |
| Pushpin Map Size: | 300 |
| Pushpin Map Caption: | Location of Grindstone Run mouth |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States of America |
| Subdivision Type2: | State |
| Subdivision Name2: | Pennsylvania |
| Subdivision Type3: | County |
| Subdivision Name3: | Lawrence |
| Subdivision Type4: | Township |
| Subdivision Name4: | Perry |
| Length: | 1.3miles[1] |
| Discharge1 Avg: | 1.32cuft/s at mouth with Slippery Rock Creek[2] |
| Source1: | divide between Slippery Rock Creek and Camp Run |
| Source1 Location: | about 3 miles north of Pyles Mills, Pennsylvania in Perry Township |
| Source1 Coordinates: | 40.9078°N -80.1803°W[3] |
| Source1 Elevation: | 1260feet[4] |
| Mouth: | Slippery Rock Creek |
| Mouth Location: | about 1 mile upstream on Slippery Rock Creek from Harris Bridge in McConnells Mill State Park |
| Mouth Coordinates: | 40.9203°N -80.2003°W |
| Mouth Elevation: | 920feet |
| Progression: | Slippery Rock Creek → Connoquenessing Creek → Beaver River → Ohio River → Mississippi River → Gulf of Mexico |
| River System: | Beaver River |
| Tributaries Left: | unnamed tributaries |
| Tributaries Right: | unnamed tributaries |
| Bridges: | Mountville Road |
Grindstone Run is a small tributary of Slippery Rock Creek in western Pennsylvania. The stream rises in eastern Lawrence County flows northwest into Slippery Rock Creek in McConnells Mill State Park.