Grindstone Creek is a stream in Clinton, DeKalb and Daviess counties in the U.S. state of Missouri. It is a tributary of the Grand River.
The stream headwaters are in northern Clinton County south of the community of Osborn at 39.7306°N -94.3669°W. The stream flows northeast through southeastern DeKalb County past the community of Fordham and passing under Missouri Route 6 1.5 miles east of Weatherby. It enters Daviess County approximately three miles northeast of Weatherby and flows north crossing under Missouri Route E one half mile west of Santa Rosa. The strem turns to the northeast for another four miles to its confluence with the Grand two miles south of Pattonsburg at 40.0189°N -94.1358°W.[1]
Grindstone Creek was named for the fact grindstones were sourced from quarries along its course.[2]