| Grigore Cazacliu | |
| Term Start: | 1917 |
| Term End: | 1918 |
| Birth Date: | 1892 1, df=y |
| Birth Place: | Cușelăuca, Soroksky Uyezd, Bessarabia Governorate |
| Death Place: | Bucharest, Romanian People's Republic |
| Relations: | Ion Cazacliu (uncle) Vladimir Cazacliu (brother) |
Grigore Cazacliu (January 25, 1892 - December 27, 1959) was a Romanian politician from Bessarabia, and a member of Sfatul Țării.
He was born in Cușelăuca, Soroksky Uyezd, Bessarabia Governorate. Cazacliu served as Member of the Sfatul Țării (the Parliament of Bessarabia) in 1917–1918, a student at the time. The Cazacliu family played an important role in the Great Union; Ion Cazacliu was Grigore's uncle, and Vladimir Cazacliu was his brother. Vladimir and Grigore Cazacliu were the sons of Alexandru and Evdochia Cazacliu; they also had a brother, Ioan, and a sister, Ludmila.
Grigore Cazacliu died in Bucharest, at age 67.