| Grigore I Ghica | |
| Succession: | Prince of Wallachia (1st reign) |
| Reign1: | 1 September 1660 – December 1664 |
| Predecessor1: | George Ghica |
| Successor1: | Radu Leon |
| Succession2: | Prince of Wallachia (2nd reign) |
| Reign2: | March 1672 – November 1673 |
| Predecessor2: | Antonie Vodă din Popești |
| Successor2: | George Ducas |
| Spouse: | Maria |
| Issue: | Matei Ghica |
| House: | Ghica family |
| Father: | George Ghica |
| Birth Date: | 1628 |
| Death Date: | 1675 |
| Death Place: | Istanbul |
| Religion: | Orthodox |
Grigore I Ghica (1628 – 1675), a member of the Ghica family, was Prince of Wallachia between September 1660 and December 1664 and again between March 1672 and November 1673.
His father was George Ghica, ruler of Moldavia (1658–59) and ruler of Wallachia (1659–60).
He married Maria, daughter of Matei Sturdza.
His son was
In 1661 he established a monastery in Focșani.[1]