Gregory Hannon Explained

Greg Hannon
Birth Name:Gregory James Hannon[1]
Workplaces:University of Cambridge
New York Genome Center
Cold Spring Harbor Laboratory
Howard Hughes Medical Institute[2]
Alma Mater:Case Western Reserve University (BA, PhD)
Thesis Title:Trans-splicing of nematode pre-messenger RNA
Thesis Url:https://search.proquest.com/docview/304045738
Thesis Year:1992
Doctoral Advisor:Timothy W. Nilsen[3]
Doctoral Students:Emily Bernstein
Notable Students:Lin He (postdoc), Camila dos Santos (postdoc)
Awards:EMBO Member (2018)[4]
Royal Society Wolfson Research Merit Award (2015)[5]
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Gregory James Hannon [6] (born 1964) is a professor of molecular cancer biology and director of the Cancer Research UK Cambridge Institute at the University of Cambridge.[7] He is a Fellow of Trinity College, Cambridge[8] [9] while also serving as a director of cancer genomics at the New York Genome Center[10] and an adjunct professor at Cold Spring Harbor Laboratory.[11]

Career and research

Hannon is known for his contributions to small RNA biology, cancer biology, and mammalian genomics.[6] He has a history in discovery of oncogenes, beginning with work that led to the identification of CDK inhibitors and their links to cancer.[6] More recently, his work has focused on small RNA biology, which led to an understanding of the biochemical mechanisms and biological functions of RNA interference (RNAi).[12] [13] [6] He has developed widely used tools and strategies for manipulation of gene expression in mammalian cells and animals and has generated genome-wide short hairpin RNA (shRNA) libraries that are available to the cancer community and was among the first to demonstrate roles for microRNAs in cancer.[6] [14] His laboratory also discovered the piwi-interacting RNA (piRNA) pathway and linked this to transposon repression and the protection of germ cell genomes.[6] His innovations include the development of selective re-sequencing strategies, broadly termed exome capture.[6]

In 2017, Hannon was awarded a £20 million Cancer Grand Challenges[15] award to unite the IMAXT team - a team of researchers from Switzerland, Ireland, Canada, the USA and the UK, with far ranging expertise from cancer biology and pathology to astronomy and even VR video game design. The team's aim is to create an interactive 3D map of cancer, which could be explored in virtual reality.[16] [17] The programme could transform the way researchers study cancer by providing unprecedented insight into how individual cells are arranged and how they interact to allow the tumour to grow.[18] [19]

In 2018, it was announced Prof Hannon would guide the Functional Genomics Centre, a collaboration between Cancer Research UK and AstraZeneca.[20] The centre, housed inside the Milner Therapeutics Institute, aims to act as a hub for genetic screens, cancer models, CRISPR tool design, and computational approaches to big data to understand genetic changes in cancer development and identify potential drug targets.[19] [21]

Awards and honours

Notes and References

  1. Greg Hannon's
  2. Web site: Gregory J. Hannon, PhD - HHMI.org.
  3. PhD . Gregory James. Hannon . Trans-splicing of nematode pre-messenger RNA . Case Western Reserve University . 1992 . 29529734. .
  4. Web site: Find people in the EMBO Communities. people.embo.org. 20 June 2018.
  5. Web site: Gregory Hannon. royalsociety.org. 20 June 2018.
  6. Web site: Professor Gregory Hannon FRS. royalsociety.org. Royal Society. London. Anon. 2018. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
  7. Web site: Greg Hannon – Hannon Laboratory. hannonlab.org. 20 June 2018.
  8. Web site: Professor Greg Hannon leads £20 million Grand Challenge project to build 3D cancer tumour. 10 February 2017 .
  9. Web site: Professor Greg Hannon appointed new Director of Cancer Research UK Cambridge Institute. 17 November 2017 .
  10. Web site: Hannon Lab @ New York Genome Center. nygenome.org. 20 June 2018.
  11. Web site: Hannon Laboratory @CSHL. hannonlab.cshl.edu.
  12. Hannon. Gregory J.. 4426281. RNA interference. Nature. 418. 6894. 2002. 244–251. 0028-0836. 10.1038/418244a. 12110901. 2002Natur.418..244H.
  13. Bernstein. Emily. Emily Bernstein. Caudy. Amy A.. Hammond. Scott M.. Hannon. Gregory J.. 4371481. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature. 10.1038/35053110. 409. 6818. 2001. 363–366. 0028-0836. 11201747. 2001Natur.409..363B.
  14. Elizabeth P.. Murchison. Elizabeth Murchison. Gregory J.. Hannon. miRNAs on the move: miRNA biogenesis and the RNAi machinery . Current Opinion in Cell Biology . 16 . 3 . 223–9 . 2004 . 15145345 . 10.1016/j.ceb.2004.04.003 .
  15. cancergrandchallenges.org/teams/imaxt
  16. Web site: U.K. cancer charity awards £71 million for four major research challenges. Kaiser. Jocelyn. 2017-02-09. Science AAAS. 2019-08-28.
  17. Web site: Cancer Research UK announces four 'Grand Challenge' teams. www.timeshighereducation.com. 10 February 2017 . 2019-08-28.
  18. News: 'Virtual tumour' new way to see cancer. Walsh. Fergus. 2018-12-26. 2019-08-28.
  19. News: Researchers are using virtual reality in the fight against cancer. Salter. Jessica. 2019-07-29. The Telegraph. 2019-08-28. 0307-1235.
  20. Web site: Cancer Research UK and AstraZeneca launch world class functional genomics centre. 2018-12-10. Cancer Research UK. 2019-08-28.
  21. Web site: AstraZeneca and CRUK launch Cambridge centre to accelerate cancer drug development. 2018-12-10. Cambridge Independent. 2019-08-28.
  22. Web site: Gregory J. Hannon, Ph.D.. pew.org. 2019-08-28.
  23. Web site: Gregory J. Hannon. Rita Allen Foundation. August 10, 2016. 2019-08-28.
  24. Web site: Press Release: Innovator Award Recipients from the DOD Breast Cancer Research Program; Congressionally Directed Medical Research Programs (CDMRP). cdmrp.army.mil. 2019-08-28.
  25. Web site: Greg Hannon awarded the 2005 AACR Award for Outstanding Achievement in Cancer Research. 2005-04-27. Cold Spring Harbor Laboratory. 2019-08-28.
  26. Web site: AACR Award for Outstanding Achievement in Cancer Research. www.aacr.org. 2019-08-28. 2019-08-28. https://web.archive.org/web/20190828153330/https://www.aacr.org/Research/Awards/PAGES/OUTSTANDING-ACHIEVEMENT-AWARD___8470D6.ASPX. dead.
  27. Web site: CSHL molecular biologist honored by National Academy of Sciences. 2007-01-17. Cold Spring Harbor Laboratory. 2019-08-28.
  28. Web site: 2007 Prize Winners. Memorial Sloan Kettering Cancer Center. 2019-08-28.
  29. Web site: Paul Marks Prize Recognizes Three Young Cancer Researchers. Memorial Sloan Kettering Cancer Center. 2019-08-28. September 26, 2007.
  30. Web site: CSHL Professor Gregory Hannon elected to U.S. National Academy of Sciences. 2012-05-01. Cold Spring Harbor Laboratory. 2019-08-28.
  31. Web site: Gregory Hannon. www.nasonline.org. 2019-08-28.
  32. Web site: Gregory Hannon Royal Society. royalsociety.org. 2019-08-28.
  33. Web site: Professor Gregory Hannon The Academy of Medical Sciences. acmedsci.ac.uk. 2019-08-28.
  34. Web site: The Academy of Medical Sciences announces new Fellows for 2017. 2017-05-08. University of Cambridge. 2019-08-28.
  35. Web site: Find people in the EMBO Communities. people.embo.org. 2019-08-28.
  36. Web site: Prof Greg Hannon elected to EMBO Membership. 2018-05-14. Cancer Research UK Cambridge Institute. 2019-08-28.
  37. Web site: Fellows European Academy of Cancer Sciences. www.europeancanceracademy.eu. 2019-11-13. 2019-07-04. https://web.archive.org/web/20190704091011/https://www.europeancanceracademy.eu/content/directory.php. dead.
  38. Web site: AACR Announces Fellows of the AACR Academy Class of 2020 AACR News Releases. 2020-06-05. American Association for Cancer Research (AACR). en.

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