| Honorific-Prefix: | Most Reverend |
| Gregorio Santacroce | |
| Bishop of Giovinazzo | |
| Church: | Catholic Church |
| Diocese: | Diocese of Giovinazzo |
| Term: | 1610–1611 |
| Predecessor: | Giovanni Antonio Viperani |
| Successor: | Giulio Masi |
| Death Date: | 1611 |
| Death Place: | Giovinazzo, Italy |
| Previous Post: | Coadjutor Bishop of Giovinazzo (1606-1610) |
Gregorio Santacroce (died 1611) was a Roman Catholic prelate who served as Bishop of Giovinazzo (1610–1611).
Gregorio Santacroce was ordained a priest in the Order of Saint Benedict. On 12 June 1606, he was appointed by Pope Paul V as Coadjutor Bishop of Giovinazzo and Titular Bishop of Dragobitia. He succeeded to the bishopric on March 1610 after the death of his predecessor. He served as Bishop of Giovinazzo until his death in 1611.