Granulibacter bethesdensis explained

Granulibacter bethesdensis is a Gram-negative, aerobic coccobacillus to rod-shaped, non-motile, catalase-positive and oxidase-negative bacteria first described in 2006 by Dr. Steve Holland's team, which included Dr. David E. Greenberg and Dr. Patrick R. Murray at the National Institutes of Health in Bethesda, Maryland.^[1]

Clinical Significance

Granulibacter bethesdensis was identified in a series of patients with chronic granulomatous disease (CGD). In a later study, nearly half of patients with CGD tested and a quarter of healthy volunteers showed some immunoreactivity to Granulibacter bethesdensis, suggesting infections with this organism occur more often than it is isolated.^[2]

External links

• LPSN
  • Type strain of Granulibacter bethesdensis at BacDive - the Bacterial Diversity Metadatabase

Notes and References

1. Greenberg. DE. Porcella SF . Stock F . Wong A . Conville PS . Murray PR . Holland SM . Zelazny AM . Granulibacter bethesdensis gen. nov., sp. nov., a distinctive pathogenic acetic acid bacterium in the family Acetobacteraceae. Int J Syst Evol Microbiol. Nov 2006. 56. Pt 11. 11. 2609–16. 17082400 . 10.1099/ijs.0.64412-0.
2. Greenberg. DE. Shoffner AR . Marshall-Batty KR . Arora K . Zhao M . Martin R . Ding L . Hammer CH . Shaw PA . Kuhns DB . Malech HL . Gallin JI . Zarember KA . Holland SM. Serologic reactivity to the emerging pathogen Granulibacter bethesdensis. J Infect Dis. Sep 2012. 206. 6. 943–51. 22782953. 10.1093/infdis/jis431. 3501152.