| Grande Saline | |
| Settlement Type: | Quartier |
| Mapsize: | 300px |
| Subdivision Type: | Country |
| Subdivision Name: |  France |
| Subdivision Type1: | Overseas collectivity |
| Subdivision Name1: | Saint Barthélemy |
| Coordinates: | 17.8972°N -62.815°W |
Grande Saline (pronounced as /fr/) is a quartier of Saint Barthélemy in the Caribbean. It is located in the southern-central part of the island.