| Río Grande | |
| Subdivision Type1: | Country |
| Subdivision Name1: | Argentina |
| Subdivision Type2: | Province |
| Subdivision Name2: | Mendoza |
| Subdivision Type3: | Department |
| Length: | 275km (171miles) |
| Discharge1 Avg: | 107m3/s |
Río Grande (Spanish for "great river") is a river located in Malargüe Department of southwestern Mendoza Province, Argentina. It arises in the confluence of the rivers Cobre and Tordillo on the Andes range near Chile and ends at the Colorado River at the Neuquén Province border. Its total length is . It's the most plentiful river of Mendoza with a flow of .
The river is from of Malargüe city and its course is development through volcanic rocks cracks. Around exists untouched earth, but the local government plans to take advantage of its resources.
Tordillo River, De la Pampa Stream, Del Infiernillo Stream, Del Totoral Stream, Carilaufquen Stream, De la Yesera Stream, Chacai-có Stream, Chequenco Stream and Agua Botada Stream