| Official Name: | Grande-Saline |
| Native Name: | Grann Salin |
| Settlement Type: | Commune |
| Pushpin Map: | Haiti |
| Pushpin Map Caption: | Location in Haiti |
| Subdivision Type: | Country |
| Subdivision Name: | Haiti |
| Subdivision Type1: | Department |
| Subdivision Name1: | Artibonite |
| Subdivision Type2: | Arrondissement |
| Subdivision Name2: | Dessalines |
| Population As Of: | 7 August 2003 |
| Population Footnotes: | [1] |
| Population Total: | 14,940 |
| Coordinates: | 19.25°N -72.7833°W |
| Elevation M: | 0 |
Grande-Saline (pronounced as /fr/; Haitian; Haitian Creole: Grann Salin) is a commune in the Dessalines Arrondissement in the Artibonite department of Haiti.