| Grande-Île Wildlife Refuge | |
| Map: | Quebec |
| Location: | Canada, Quebec, D'Autray Regional County Municipality |
| Nearest City: | Berthierville |
| Coords: | 46.1236°N -73.0278°W |
| Area: | 145 |
| Authorized: | Ministère des Ressources naturelles et de la Faune du Québec |
| Created: | 1992 |
The Grande-île Wildlife Refuge is a protected area of Quebec located in Saint-Ignace-de-Loyola in the D'Autray Regional County Municipality and one of the province's 11 wildlife refuges. This site on Great Island protects one of the largest Heron of North America.