| Official Name: | Grand Isle, Maine |
| Settlement Type: | Census-designated place |
| Pushpin Map: | Maine#USA |
| Pushpin Label: | Grand Isle |
| Coordinates: | 47.3078°N -68.1547°W |
| Subdivision Type: | Country |
| Subdivision Type1: | State |
| Subdivision Name1: | Maine |
| Subdivision Type2: | County |
| Subdivision Name2: | Aroostook |
| Subdivision Type3: | Town |
| Subdivision Name3: | Grand Isle |
| Area Footnotes: | [1] |
| Area Total Sq Mi: | 0.69 |
| Area Land Sq Mi: | 0.62 |
| Area Water Sq Mi: | 0.07 |
| Area Total Km2: | 1.80 |
| Area Land Km2: | 1.60 |
| Area Water Km2: | 0.19 |
| Population As Of: | 2020 |
| Population Density Km2: | 114.68 |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation Ft: | 495 |
| Postal Code Type: | ZIP Code |
| Postal Code: | 04746 |
| Area Code: | 207 |
| Blank Name: | FIPS code |
| Blank Info: | 23-28555 |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 2804663 |
| Population Total: | 184 |
| Unit Pref: | Imperial |
| Population Density Sq Mi: | 297.25 |
Grand Isle is a census-designated place (CDP) and the primary village in the town of Grand Isle, Aroostook County, Maine, United States. It is in the northwestern corner of the town, situated on high ground overlooking the St. John River, which forms the Canada–United States border. The Canadian province of New Brunswick is to the northeast across the river.
U.S. Route 1 passes through Grand Isle, leading northwest 9miles to Madawaska and southeast to Van Buren.
Grand Isle was first listed as a CDP prior to the 2020 census.