| Grand'Combe-Châteleu | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason ville fr Grand'Combe-Châteleu (Doubs).svg |
| Coordinates: | 47.0269°N 6.5706°W |
| Insee: | 25285 |
| Postal Code: | 25570 |
| Arrondissement: | Pontarlier |
| Canton: | Morteau |
| Mayor: | Christelle Vuillemin[1] |
| Term: | 2023 - 2026 |
| Intercommunality: | Val de Morteau |
| Elevation Min M: | 750 |
| Elevation Max M: | 1300 |
| Area Km2: | 21.46 |
Grand'Combe-Châteleu (in French pronounced as /ɡʁɑ̃kɔ̃b ʃatlø/) is a commune in the Doubs department in the Bourgogne-Franche-Comté region in eastern France.