| Graffignana | |
| Official Name: | Comune di Graffignana |
| Coordinates: | 45.2°N 39°W |
| Region: | Lombardy |
| Province: | Lodi (LO) |
| Mayor: | Giuseppe Enrico Galetta |
| Area Total Km2: | 10.7 |
| Population Footnotes: | [1] |
| Population Total: | 2624 |
| Population As Of: | 31 August 2017 |
| Population Demonym: | Graffignanini |
| Elevation M: | 67 |
| Saint: | Sts. Peter and Paul |
| Day: | 29 June |
| Postal Code: | 26813 |
| Area Code: | 0371 |
Graffignana (Lodigiano: Grafignàn) is a comune (municipality) in the Province of Lodi in the Italian region Lombardy, located about 40km (30miles) southeast of Milan and about 13km (08miles) south of Lodi.
Graffignana borders the following municipalities: Sant'Angelo Lodigiano, Villanova del Sillaro, Borghetto Lodigiano, San Colombano al Lambro, Miradolo Terme.