| Gradefes, Spain | |
| Pushpin Map: | Spain |
| Coordinates: | 42.6247°N -5.2272°W |
| Subdivision Name3: | Gradefes |
| Leader Title: | Mayor |
| Leader Name: | Ana Isabel Ferreras Díez |
| Leader Party: | PSOE |
| Area Total Km2: | 205.86 |
| Elevation M: | 852 |
| Population Density Km2: | auto |
| Utc Offset: | +1 |
| Utc Offset Dst: | +2 |
| Population Demonym: | gradefense; gradefeño, gradefeña |
| Postal Code Type: | Postal Code |
| Postal Code: | 24160 |
| Area Code Type: | Telephone prefix |
| Area Code: | 987 |
Gradefes (pronounced as /es/) is a municipality located in the province of León, Castile and León, Spain., the municipality has a population of 1,076 inhabitants.
Sights include the all-female Cistercian monastery of Santa María la Real, founded in 1177, the church of San Miguel de Escalada, the parish church of the Assumption (12th century, in the hamlet of Villarmún), and the ruined monastery of San Pedro de Eslonza.