| Grésigny-Sainte-Reine | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason de la ville de Grésigny-Sainte-Reine (Côte-d'Or).svg |
| Arrondissement: | Montbard |
| Canton: | Montbard |
| Insee: | 21307 |
| Postal Code: | 21150 |
| Mayor: | Eric Perrin[1] |
| Term: | 2020 - 2026 |
| Coordinates: | 47.5581°N 4.5025°W |
| Elevation M: | 255 |
| Elevation Min M: | 238 |
| Elevation Max M: | 400 |
| Area Km2: | 7.06 |
Grésigny-Sainte-Reine (in French pronounced as /ɡʁeziɲi sɛ̃t ʁɛn/) is a commune in the Côte-d'Or department in eastern France.