| Gobernador Dupuy Department | |
| Native Name Lang: | es |
| Settlement Type: | Department |
| Seat: | Buena Esperanza |
| Population: | 11,120 |
| Coordinates: | -34.75°N -80°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Area Total Km2: | 19,632 |
Gobernador Dupuy is a department of San Luis Province, Argentina.
With an area of 19632sqkm it is the biggest department in the province. It borders to the north with the departments of Juan Martín de Pueyrredón and General Pedernera, to the east with the provinces of Córdoba and La Pampa, to the south with La Pampa and to the west with Mendoza Province.